I think Andy_P had touched on this elsewhere a few days ago and I have posted for years that I had stopped using itineraries.
Instead, I have made multiple POIs to City Center (fastest way to select).
I used to have an itinerary to go from Toronto, ON to Albany, NY, driving typically twice a year.
I gave our friends an ETA and depending on stops would make some detours from the planned route.
Driving through the Adirondacks, having some time to spare and seeing an interesting road going off the appointed one, I would take it. Then I had to constantly see that the device wanted me to take a turn at every intersecting road or even suggesting a U-turn.
I switched to city centre POIs only and selected the next one I should pass.
Within a few miles of getting to the city limits I would punch in the following city and get on the fastest way through or around the previously chosen one.
I don't know Tyre PRO so I cannot say if route optimisation is included. It was not in basic Tyre so it was of no use to a business person.